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Short-term efficacy. It is well established that hyperglycemia, expressed as elevated HbA 1c, is associated with the risk of microvascular and macrovascular complications. Citation 11 Reduced rates of microvascular complications in well controlled type 2 diabetic patients were proven by prospective randomized trials. Citation 12, Citation 13 Thus the American Diabetes Association's.
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2.1. Patients. This was an observational PMS conducted in accordance with the Japanese Good Post-marketing Study Practice guidelines. Patients were centrally registered from April 2010 to April 2012 and were observed for up to 36 months until March 2015 across 775 clinics and hospitals throughout Japan.
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December 17, 2019 / 09:07 PM IST. The Rs 15,000 crore Indian anti-diabetes drug market is in for a shake-up as companies shift their focus towards promoting the latest generation of SGLT2.
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TR2010/10683A 2010-12-21 Vildagliptin formulations. The invention is a pharmaceutical formulation comprising vildagliptin granules having at least one coating layer and one or more excipients. More particularly, the invention relates to a tablet or capsule formulation of vildagliptin with a stable and desired level of solubility and dissolution.
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The ฮ63 patent discloses a synthesis of Vildagliptin using the synthetic process represented in Scheme 1. However, the preparation process of Vildagliptin intermediate, 1-chloro acetyl (S)-2- c ano pyrrolidine has some problems. The acylation of (S)-prolinamide of the formula. with chloroacetyl chloride of the formula.
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Patent Application Publication Jul. 10, 2008 US 2008/O167479 A1 O 630 560 49 2O 350 28 210 1400 I Illal. W -Wiwa Maa 2 34 39 44 49 54
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The patent application WO00/34241 discloses vildagliptin or an acid addition salt thereof, as well as their use in diabetes mellitus and obesity. The patent application WO2006/078593 claims a direct-compression formulation of a DPP-IV inhibitor compound, and preferably of vildagliptin or an acid addition salt thereof.
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2โฒS)-1,1โฒ-[[(3-hydroxytricyclo[3.3.1.1 3,7 ]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and.
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Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. 2 By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and.
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Vildagliptin is an amino acid amide. Vildagliptin (LAF237) is an orally active antihyperglycemic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme. It is used to manage type II diabetes mellitus, where GLP-1 secretion and insulinotropic effects are impaired. By inhibiting DPP-4, vildagliptin prevents the degradation of.
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The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable salt thereof and a diluent. Particularly, the ratio of vildagliptin to diluent is in the range of 0.04 to 0.24 (w/w).
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US-2017014379-A1 chemical patent summary.
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Vildagliptin, sold under the brand name Galvus and others, is an oral anti-hyperglycemic agent (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Vildagliptin inhibits the inactivation of GLP-1 and GIP by DPP-4, allowing GLP-1 and GIP to potentiate the secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of.
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NOVARTIS AG (CH) Country. Cyprus. Dates. Priority: 2005/09/29. Description. This web page summarizes information in PubChem about patent CY-1112305-T1. This includes chemicals mentioned, as reported by PubChem contributors, as well as other content, such as title, abstract, and International Patent Classification (IPC) codes.
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Justia Patents US Patent Application for Pharmaceutical Formulations of Vildagliptin Patent Application (Application #20170014379) Pharmaceutical Formulations of Vildagliptin . Mar 5, 2015. The present invention relates to a pharmaceutical formulation comprising therapeutically effective amount of vildagliptin or pharmaceutically acceptable.
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The present invention relates to a process for preparing vildagliptin of formula (I) with high chemical and enantiomeric purity and compositions comprising vildagliptin. In addition, the present invention relates to (2S,2โฒS)-1,1โฒ-[[(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)imino]bis(1-oxo-2,1-ethanediyl)]di(2-pyrrolidinecarbonitrile) of formula (II), processes for preparing, and compositions.