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The present invention relates to an improved process for the production of 7- [2- (2-aminpthiazol-4-yl)-2-syn-methoxyiminoacetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) and its sodium salt. The synthesis of Cefotaxime includes the reaction of 2- (2-chloroacetamidothiazol-4-yl)-2-syn-methoxyiminoacetyl chloride with 7.
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Cefotaxime injection is used to treat bacterial infections in many different parts of the body. This medicine is also given before, during, and after certain types of surgery to prevent infections. Cefotaxime injection belongs to the class of medicines known as cephalosporin antibiotics.
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PATIENT & CAREGIVER EDUCATION Cefotaxime This information from Lexicomp explains what you need to know about this medication, including what it's used for, how to take it, its side effects, and
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A process for the production of 7-[2-(2-amino-4-thiazolyl)-2-syn-methoxyimino-acetamido]-3-acetoxymethyl-3-cephem-4-carboxylic acid (Cefotaxime) in aqueous isopropyl alcohol is provided. The synthesis provides the product in greater than 99 % HPLC purity.
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Cefotaxime. Cefotaxime is an antibiotic used to treat a number of bacterial infections in human, other animals and plant tissue culture. [3] Specifically in humans it is used to treat joint infections, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, sepsis, gonorrhea, and cellulitis. [3]
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Crystalline sodium salt of cefotaxime is separated by filtration, washed with acetone and dried overnight in a vacuum drying chamber at 40°. Yield: 36.6 g; Content of the sodium salt of cefotaxime: 95.9%; Water content: 3.8%. EXAMPLE 3 Production of cefotaxime. 228.3 g of 7-ACA are suspended in 720 ml of acetone.
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Funding from French Government as part of the France Health Innovation Plan 2030 operated by Bpifrance PARIS, Feb. 1, 2024 /PRNewswire/ -- Vivet Therapeutics ("Vivet"), a clinical stage biotech company developing novel and long-lasting gene therapies for rare inherited metabolic disorders, announces the financing of EUR 4.9 million received from the French government to advance the development.
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The Cefotaxime top 50 is Discovery PatSnap' annual ranking of the top 50 Most Patent Filings Cefotaxime Key Players in the world. Discovery has identified the top key players, startups & unicorns, fast-growings, news entrants in 2022, ranking from differnt perspectives, including patent filing intensity, academic research capability, news media heat.
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Production of the sodium salt of cefotaxime 6 g of sodium acetate trihydrate are dissolved in 20 ml of water. 40 ml of acetone and 20 g of cefotaxime in free acid form are added to the stirred solution. The mixture is cooled to 0°. A solution is obtained within 2 to 5 minutes.
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It does not have activity against Pseudomonas aeruginosa. Cefotaxime works by inhibiting bacterial cell wall biosynthesis. A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives. Mechanism of action.
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Abstract. Cefotaxime is a new 'third generation' semisynthetic cephalosporin administered intravenously or intramuscularly. It has a broad spectrum of activity against Gram-positive and Gram-negative aerobic and anaerobic bacteria, and is generally more active against Gram-negative bacteria than the 'first' and 'second generation' cephalosporins.
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Cefotaxime is a medication used to manage and treat cervicitis/urethritis and pneumonia. Cefotaxime is a beta-lactam antibiotic classified as a third-generation cephalosporin. Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria affecting the lower respiratory tract, genito-urinary tract, central nervous system, intra-abdominal infections, bone.
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Cefotaxime | C16H17N5O7S2 | CID 5742673 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities.
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A population pharmacokinetic model was developed to describe cefotaxime pharmacokinetics and associated variability in adult ICU patients. The estimated creatinine clearance partly explained the IIV in cefotaxime clearance. However, the remaining unexplained IIV is high and suggests a need for dose individualisation using therapeutic drug.